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View inline View popup Download powerpoint. PLoS Med ; 6: Larger, longer, and higher-quality trials of controlled fructose feeding that also weigh any possible glycemic benefit against adverse metabolic effects are required for definitive confirmation of these findings. Global Diabetes Prevention Interventions: Oleomargarine Act requires prominent labeling of colored oleomargarine, to distinguish it from butter. Food labels are to list the most important nutrients in an easy-to-follow format.
A systematic review and meta-analysis of controlled feeding trials
We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Skip to main content. Diabetes Care Jul; 35 7: Data extraction Reports that met the inclusion criteria were each independently reviewed and extracted by at least two investigators with a standardized form. RESULTS Search results A total of 4, eligible reports were identified with the search; of these, 4, were determined to be irrelevant on review of the titles and abstracts.
Figure 1 Flowchart of literature search for the effect of fructose on glycemic end points fasting glucose, fasting insulin, and glycated blood proteins [HbA 1c and glycated albumin].
View inline View popup Download powerpoint. Table 1 Characteristics of experimental trials included in the meta-analysis. Download figure Open in new tab Download powerpoint.
Figure 2 Forest plot of controlled feeding trials investigating the effect of isocaloric exchange of fructose for other carbohydrate on A glycated blood proteins HbA 1c and glycated albumin , B fasting glucose, and C fasting insulin.
Publication bias Supplementary Figs. Footnotes Clinical trial reg. The World Health Report Life in the 21st Century: A Vision for All. Geneva, World Health Organization, Canadian Diabetes Association clinical practice guidelines for the prevention and management of diabetes in Canada.
Can J Diabetes ; Height, predictors of C-peptide and cancer risk in men. Int J Epidemiol ; National estimates of dietary fructose intake increased from to in the United States. J Nutr ; Intakes and food sources of fructose in the United States. Am J Clin Nutr ; 58 Suppl: Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity.
Am J Clin Nutr ; Nutrition recommendations and interventions for diabetes: Diabetes Care ; 31 Suppl. S61 — S78 pmid: Evidence-based nutritional approaches to the treatment and prevention of diabetes mellitus. Nutr Metab Cardiovasc Dis ; Metabolic effects of dietary sucrose and fructose in type II diabetic subjects.
Diabetes Care ; Osei K , Bossetti B. Dietary fructose as a natural sweetener in poorly controlled type 2 diabetes: Diabet Med ; 6: Metabolic effects of fructose as a natural sweetener in the physiologic meals of ambulatory obese patients with type II diabetes.
Am J Med ; Metabolic effects of fructose supplementation in diabetic individuals. Fructose and insulin sensitivity in patients with type 2 diabetes. J Intern Med ; Effets metaboliques de la consommation quotidienne pendant un an de saccharose ou de fructose par des diabetiques. Médecine et Nutrition ; Metabolic effects of dietary fructose and sucrose in types I and II diabetic subjects. JAMA ; Cochrane Handbook for Systematic Reviews of Interventions. Oxford, UK , Cochrane Collaboration , Accessed on 15 May Preferred reporting items for systematic reviews and meta-analyses: PLoS Med ; 6: Should immunonutrition become routine in critically ill patients?
A systematic review of the evidence. Meta-analyses involving cross-over trials: Metabolic effects of dietary fructose in diabetic subjects. Lack of detectable deleterious effects on metabolic control of daily fructose ingestion for 2 mo in NIDDM patients. Long-term effects of dietary fructose on carbohydrate metabolism in non-insulin-dependent diabetes mellitus. Metabolism ; Catalytic amounts of fructose may improve glucose tolerance in subjects with uncontrolled non-insulin-dependent diabetes.
Clin Nutr ; Metabolic effects of dietary fructose in insulin dependent diabetes of adults. Acta Med Scand Suppl ; Effect of dietary fructose on triglyceride transport and glucoregulatory hormones in hypertriglyceridemic men.
Metabolic consequence of two-week fructose feeding in diabetic subjects. Diabetes Care ; 9: The effects of one month high fructose intake on plasma glucose and lipid levels in non-insulin-dependent diabetes. Diabet Med ; 4: Lipid metabolism in non-insulin-dependent diabetes: Center for Drug Evaluation and Research.
Rockville, Md , U. Oral antihyperglycemic therapy for type 2 diabetes: Livesey G , Taylor R. Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: Diabetes Care ; 6: Heterogeneous effects of fructose on blood lipids in individuals with type 2 diabetes: International tables of glycemic index and glycemic load values: The use of low-glycaemic index diets in diabetes control.
Br J Nutr ; Fructose improves the ability of hyperglycemia per se to regulate glucose production in type 2 diabetes. Diabetes ; Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans. Observations on the decay of glycated hemoglobin HbA1c in diabetic patients. Exp Clin Endocrinol Diabetes ; Effect of fructose on glycemic control in diabetes: Search for this keyword. Sign up to receive current issue alerts. View Selected Citations 0.
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Sievenpiper , Russell J. Yu , Amanda J. Jenkins , Lawrence A. Leiter , Thomas M. Wolever , Joseph Beyene , Cyril W. Kendall , David J.
Add to Selected Citations. Global Diabetes Prevention Interventions: After repeated debilitation and stakeholder pressures, the law finally went into effect only 7 years later, on March 16, , and even then with many loopholes. Announcement made that FDA will require food labels to include trans-fat content. Labeling went into effect in The FDA announced plans to permit the manufacturers of food products sold in the United States to make health claims that are supported by less than conclusive evidence.
Opponents criticize it as opening the door to ill-founded claims. Advocates believe it will make more information available to the public. The following year Kraft launches a similar initiative, called Sensible Solutions. Hannaford Supermarkets launches Guiding Stars, intended to help customers choose healthy foods.
Foods are ranked 0 to 3 stars, with three stars awarded to most nutritious foods. Front-of-package information includes daily percentage values for 6 nutrients. NuVal announced—the nutritional value NuVal system scores food on a scale of 1 to The higher the NuVal Score, the higher the nutrition of a food product.
Smart Choices launches formally with several hundred products labeled with the green checkmark. Froot Loops becomes the poster child for everything wrong with an industry-backed nutrition rating system. A week later the Smart Choices program suspends itself. Without much followup to this pilot, it seems to have fizzled away.
The Grocery Manufacturers Association announces Nutrition Keys now called Facts Up Front , a new front- of-pack labeling system, just months before the FDA is to issue its guidance to industry on the matter.
The standards are the most stringent to be seen from the food industry so far.