The drug's off-label users were mostly bodybuilders and weight lifters. Archived from the original on 24 July Views Read Edit View history. A number of severe side effects can occur if adolescents use AAS. Most of the negative feedback effect of androgens is caused by their estrogenic metabolites produced by aromatization. The measurement of the dissociation between anabolic and androgenic effects among AAS is based largely on a simple although arguably unsophisticated and outdated model involving rat tissue bioassays. Large-scale long-term studies of psychiatric effects on AAS users are not currently available.
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