Absorption and emptying
Hemorrhagic Gastroenteritis in Small Animals. Human systems and organs. It is found in the blood, gastric juices, pancreatic secretions, intestinal juices and adipose tissues. Axe on Facebook Dr. The pain associated with a stomach ulcer is caused by the ulcer itself and stomach acid that comes into contact with the ulcer and irritates it.
Children and Teens
Abnormalities on CBC are usually limited to hemoconcentration and neutrophilic leukocytosis. Serum biochemical profile may be unremarkable or show mild panhypoproteinemia, hypoglycemia sepsis, decreased intake with limited hepatic glycogen stores , and electrolyte abnormalities consistent with GI loss and decreased intake ie, hypokalemia, hyponatremia, hypochloremia. There have been anecdotal reports of mildly prolonged Trichuris vulpis , Ancylostoma spp, Uncinaria spp gastroenteritis; systemic disturbances with secondary GI involvement eg, hypoadrenocorticism, pancreatitis, renal failure, hepatic disease, etc ; coagulopathy eg, rodenticide toxicosis, thrombocytopenia, thrombocytopathia, etc ; severe GI ulceration; neoplasia; and GI perforation of any etiology.
Aggressive IV fluid therapy is the mainstay of treatment. The rate of isotonic fluid administration is based on patient perfusion, degree of dehydration, and ongoing losses. Dogs markedly hypoproteinemic or in shock may benefit from synthetic or natural colloid stored or fresh frozen plasma therapy.
In a prospective study of dogs with HGE and no clinical indices of sepsis, treatment with amoxicillin -clavulanic acid did not affect mortality rate, duration of hospitalization, or severity of clinical signs.
This might suggest not all cases of HGE are due to primary bacterial infection or that the bacteria involved may not be susceptible to amoxicillin -clavulanic acid.
Hypoglycemic dogs require dextrose supplementation 2. Additional supportive care, including antiemetic therapy and dietary management, are as described above see Canine Parvovirus and see Acute Gastritis. Prognosis is good with appropriate treatment.
However, serious complications, including marked hypoproteinemia, DIC, sepsis, hypovolemic shock, and death, can occur. Cardiology is not a required rotation at OVC, but I picked it up nonetheless because it is one of my weakest subjects.
Hemorrhagic Gastroenteritis in Small Animals. Also of Interest Quiz Dental Development. The trypsins proteolytic enzymes secreted by the pancreas are much more powerful than pepsins, so the greater part of protein digestion occurs in the duodenum and upper jejunum. Therefore, even after total removal of the stomach, protein digestion usually is not impaired. Pancreatic secretion contains inactive protease precursors that become enzymatically active after interacting with another enzyme, enterokinase , which is secreted from the microvillous component of the enterocytes in the duodenal and jejunal mucosa.
Trypsinogen is activated in the intestine by enterokinase, which is liberated from duodenal lining cells by the interaction of bile acids and CCK. This activation of trypsinogen to trypsin is initiated by the cleavage from it of six terminal amino acid residues.
The other proteases are activated by free trypsin. The net effect of these proteases is to reduce dietary proteins to small polypeptide chains of two to six amino acids and to single amino acids.
Trypsin activates the other pancreatic proteases, including chymotrypsin and elastase. Trypsin, chymotrypsin, and elastase are known as endopeptidases and are responsible for the initial breakdown of the protein chains to peptides by hydrolysis. The next step, the breakdown of these peptides to smaller molecules and then to individual amino acids, is brought about by the enzymic activity of carboxypeptidases, which are also secreted by the pancreas.
Peptidase activity commences outside the enterocytes in the mucus and brush border and continues inside the cell. A different peptidase appears to be involved in each stage of the breakdown of protein to amino acids. Likewise, the transport of different peptides involves different mechanisms.
Dipeptides peptides that release two amino acids on hydrolysis and tripeptides peptides that release three amino acids are moved from the surface brush border into the cell by an energy-requiring process involving a carrier protein. Small peptides with few amino acids are absorbed directly as such. The greater part of the breakdown of peptides to amino acids takes place within the enterocyte. Curiously, small peptides are absorbed more rapidly than amino acids, and, indeed, the precise details of the mechanism for absorption of amino acids are largely unknown.
It is known that some amino acids have a specific individual transport system while others share one. Amino acids may be classified into groups, depending upon their optical rotatory characteristics i. Levorotatory amino acids are absorbed extremely rapidly—much more rapidly than are dextrorotatory amino acids.
In fact, levorotatory amino acids are absorbed almost as quickly as they are released from protein or peptide. Neutral amino acids have certain structural requirements for active transport, and if these specific structural arrangements are disturbed, active transport will not occur.
Basic amino acids, which have a pH above 7, are transported at about 5 to 10 percent of the rate of neutral levorotatory amino acids. We welcome suggested improvements to any of our articles. You can make it easier for us to review and, hopefully, publish your contribution by keeping a few points in mind.
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Proteins The digestion of protein entails breaking the complex molecule first into peptides, each having a number of amino acids , and second into individual amino acids. Previous page Islet cells. Page 18 of Learn More in these related Britannica articles: A number of alterations, often causing more or less distress, occur in the physical condition and functions of the gastrointestinal tract during pregnancy.